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Hepatitis C Virions Group Portrait.The image here is 400 pixels across, the original measures 3000 x 4237 pixels.EXPLANATION OF HEPATITIS C VIRUS (HCV) GROUP IMAGE: This image shows the viral model from several different viewpoints. The orange spikes covering the surface represent the E (Envelope) Proteins. Each spike is a dimer of E1 and E2 anchored into the viral envelope (illustrated as a greenish-blue layer). This viral envelope is derived from host cell ER membrane. Below that is a purplish layer representing the core (C) proteins. In the core lies the RNA genome. It is not known whether p7 (a small protein that may hexamerise into a viroporin) is present in the virion. Hepatitis C Virus (HCV) is a small enveloped + single stranded RNA virus. It classified in the family Flaviviridae (L. Flavus: yellow named after Yellow Fever) in the genus Hepacivirus.ACKNOWLEDGEMENTS: With many thanks to Professor Eric Gowans at the Macfarlane Burnet Institute in Melbourne Australia for his helpful discussions, advice and comments. Modelling and rendering done using Martin Wengenmayers CHEETAH 3D software. REFERENCES Branch AD. Replication of Hepatitis C Virus: Catching It in the Act. HEPATOLOGY, Vol. 23, No. 2, 1996, 372 Carrere-Kremer S, Montpellier-Pala C, Cocquerel L Wychowski C, Penin F & Dubuisson J. Subcellular Localization and Topology of the p7 Polypeptide of Hepatitis C Virus. Journal of Virology Apr 2002, Vol. 76, No. 8, p. 3720-3730 Clayton RF, Owsianka A, Aitken J, Graham S, Bhella D, & Patel AH. Analysis of Antigenicity and Topolgy of E2 Glycoprotein Present on Recombinant Hepatitis C Virus-Like Particles. Journal of Virology Aug 2002, Vol. 76, No. 15, p. 7672-7682 De Beeck AO, Cocquerel L & Dubuisson J. Biogenesis of hepatitis C virus envelope glycoproteins. Journal of General Virology (2001), 82, 2589-2595 Harada T, Tautz N, & Thiel HJ. E2-p7 Region of the Bovine Viral Diarrhea Virus Polyprotein: Processing and Functional Studies. Journal of Virology Oct 2000, Vol. 74, No. 20, p. 9498-9506 Nielsen SU, Bassendine MF, Burt AD, Bevitt DJ & Toms GL. Characterization of the genome and structural proteins of hepatitis C virus resolved from infected human liver. Journal of General Virology (2004), 85, 1497-1507 Penin F, Dubuisson J, Rey FA, Moradpour D, Pawlotsky JM. Structural Biology of Hepatitis C Virus. HEPATOLOGY, Vol. 39, No. 1, 2004 Shimizu YK, Feinstone SM, Kohara M, Purcell RH, Yoshikura H. Hepatitis C Virus: Detection of Intracellular Virus Particles by Electron Microscopy. HEPATOLOGY, Vol. 23, No. 2, 1996 4. Ishida S, Kaito M, Kohara M, Tsukiyama-kohora K, Fujita N, Ikoma J, Adachi Y, Wantanabe S. Hepatitis C virus core particle detected by immunoelectron microscopy and optical rotation technique. Hepatology Reseach 20 (2001) 335-347 4. Lo SY, SElby MJ & Ou JH. Interaction between Hepatitis C Virus Core Protein and E1 Envelope Protein. Journal of Virology Aug 1996, Vol. 70, No. 8, p. 5177-5182 |